Peter Parker/Spider-Man

饰：汤姆·赫兰德

MJ

饰：赞达亚

Doctor Strange

饰：本尼迪克特·康伯巴奇

May Parker

饰：玛丽莎·托梅

Wong

饰：本尼迪特·王

Otto Octavius /Doctor Octopus

饰：阿尔弗雷德·莫里纳

Green Goblin

Max Dillon / Electro

The Lizard / Dr. Curt Connors

Mr. Harrington

J. Jonah Jameson

Matt Murdock

Ned Leeds

Betty Brant

Mr. Dell

Flash Thompson

Drug Dealer

Coach Wilson

Shield Agent

Andrew Reeder

High School Student

Protestor

Peter Parker

Mary Jane Watson

Sandman

Green Goblin

饰：威廉·达福

Max Dillon / Electro

饰：杰米·福克斯